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KMID : 0624620160490060331
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BMB Reports
2016 Volume.49 No. 6 p.331 ~ p.336
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Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules
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Park Yoon-Kyung
Jung Sun-Do
Park Se-Ho
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Abstract
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In murine collagen-induced arthritis (CIA), self-reactive T cells can recognize peptide antigens derived from type-II collagen (CII). Activation of T cells is an important mediator of autoimmune diseases. Thus, T cells have become a focal point of study to treat autoimmune diseases. In this study, we evaluated the efficacy of recombinant MHC class II molecules in the regulation of antigen-specific T cells by using a self peptide derived from CII (CII260-274; IAGFKGEQGPKGEPG) linked to mouse I-Aq in a murine CIA model. We found that recombinant I-Aq/CII260-274 molecules could be recognized by CII-specific T cells and inhibit the same T cells in vitro. Furthermore, the development of CIA in mice was successfully prevented by in vivo injection of recombinant I-Aq/CII260-274 molecules. Thus, treatment with recombinant soluble MHC class II molecules in complex with an immunodominant self-peptide might offer a potential therapeutic for chronic inflammation in autoimmune disease such as rheumatoid arthritis.
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KEYWORD
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Collagen-induced arthritis, Immunotherapy, Rheumatoid arthriti, Recombinant MHC II, Type-II collagen
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